Carm down Mia/Nia
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Spoiler Alert!

This article contains spoilers for Resident Evil 7. Proceed with caution.
When Joe streamed Resident Evil 7, he accidentally said "carm" instead of "calm".[1] Then in one part of the game, the protagonist gets stabbed through the hand by a character called Mia, and Joe thought that his reaction to this was way too understated. So he said that it was ridiculous that all the protagonist said was "Calm down, Mia" (even though he didn't actually say that).[2] Then because people in chat were still saying "carm", he started saying "Carm down, Mia".
In Xenoblade Chronicles 2 there's a character called Nia, so Joe said to her "Carm down, Nia" sometimes.[3]
References
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“Joseph Anderson Channel Two” video: “Resident Evil 7 Stream One” at 00:49:57.
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“Joseph Anderson Channel Two” video: “Resident Evil 7 Stream One” at 00:56:36.
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“Joseph Anderson Channel Two” video: “Xenoblade Chronicles 2 - A Comedy Game (Stream Two)” at 00:34:05.